Lesch, Stefanie (2019): Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models. Dissertation, LMU München: Faculty of Medicine |
Preview |
PDF
Lesch_Stefanie.pdf 7MB |
DOI: 10.5282/edoc.25031
Abstract
CXCL16 was identified to be a highly expressed cytokine in human and murine pancreatic cancer. T cells do not express the receptor for CXCL16 (CXCR6). Using retroviral transduction tumor-specific T cells can be genetically modified to express CXCR6 resulting in an enhanced trafficking and tumor cell killing in vitro and in vivo.
Item Type: | Theses (Dissertation, LMU Munich) |
---|---|
Keywords: | adoptive T cell therapy, chemokine receptors, solid tumors |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | English |
Date of oral examination: | 15. October 2019 |
1. Referee: | Kobold, Sebastian |
MD5 Checksum of the PDF-file: | f8e89d0c779b96cb57cfc1b068081568 |
Signature of the printed copy: | 0700/UMD 19254 |
ID Code: | 25031 |
Deposited On: | 19. Oct 2020 13:01 |
Last Modified: | 23. Oct 2020 14:53 |
Repository Staff Only: item control page