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Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models
Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models
CXCL16 was identified to be a highly expressed cytokine in human and murine pancreatic cancer. T cells do not express the receptor for CXCL16 (CXCR6). Using retroviral transduction tumor-specific T cells can be genetically modified to express CXCR6 resulting in an enhanced trafficking and tumor cell killing in vitro and in vivo.
adoptive T cell therapy, chemokine receptors, solid tumors
Lesch, Stefanie
2019
English
Universitätsbibliothek der Ludwig-Maximilians-Universität München
Lesch, Stefanie (2019): Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models. Dissertation, LMU München: Faculty of Medicine
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Abstract

CXCL16 was identified to be a highly expressed cytokine in human and murine pancreatic cancer. T cells do not express the receptor for CXCL16 (CXCR6). Using retroviral transduction tumor-specific T cells can be genetically modified to express CXCR6 resulting in an enhanced trafficking and tumor cell killing in vitro and in vivo.