Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models

Lesch, Stefanie (2019): Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models. Dissertation, LMU München: Faculty of Medicine

Abstract

CXCL16 was identified to be a highly expressed cytokine in human and murine pancreatic cancer. T cells do not express the receptor for CXCL16 (CXCR6). Using retroviral transduction tumor-specific T cells can be genetically modified to express CXCR6 resulting in an enhanced trafficking and tumor cell killing in vitro and in vivo.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: adoptive T cell therapy, chemokine receptors, solid tumors
• Subjects: 600 Technology, Medicine; 600 Technology, Medicine > 610 Medical sciences and medicine
• Faculties: Faculty of Medicine
• Language: English
• Date of oral examination: 15. October 2019
• 1. Referee: Kobold, Sebastian
• Signature of the printed copy: 0700/UMD 19254