Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models

Lesch, Stefanie (2019): Engineering model antigen-specific T cells to overexpress the chemokine receptor CXCR6 improves homing of adoptively transferred T cells in subcutaneous tumor models. Dissertation, LMU München: Medizinische Fakultät

Abstract

CXCL16 was identified to be a highly expressed cytokine in human and murine pancreatic cancer. T cells do not express the receptor for CXCL16 (CXCR6). Using retroviral transduction tumor-specific T cells can be genetically modified to express CXCR6 resulting in an enhanced trafficking and tumor cell killing in vitro and in vivo.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: adoptive T cell therapy, chemokine receptors, solid tumors
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 15. Oktober 2019
• 1. Bericht­erstatter:in: Kobold, Sebastian