Immunhistochemische Visualisierung von Cathepsin D und Glycodelin A am Mammakarzinom

Barthell, Elisabeth (2008): Immunhistochemische Visualisierung von Cathepsin D und Glycodelin A am Mammakarzinom. Dissertation, LMU München: Medizinische Fakultät

Abstract

121 breast cancer tumours were stained immunohistochemically with Cath D mouse antibody and Gd A monoclonal mouse and polyklonal rabbit antibody. For Cath D tumours with positive lymph nodes showed significant higher expression as well as ductal carcinomas compared to lobal carcinomas. For Gd A the monoclonal antibody showed a positive correlation of staining with positive steroid receptors (Estrogen and Progesteron). There was no association with grading. The results fit into the concept of breakdown of extracellular matrix by Cath D and its role in tumour progression and metastasis as well as immunosuression an d the rolr in tumourogenesis of Gd.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Cathepsin D, Glycodelin A, Immunhistochemistry, breast cancer, hormone receptors,
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Deutsch
• Datum der mündlichen Prüfung: 20. November 2008
• 1. Bericht­erstatter:in: Jeschke, Udo