Vergleich von Alkoholabhängigen mit und ohne Vorgeschichte von Suizidversuchen anhand von klinischen und neurobiologischen Parametern

Karakesisoglou, Aliki (2007): Vergleich von Alkoholabhängigen mit und ohne Vorgeschichte von Suizidversuchen anhand von klinischen und neurobiologischen Parametern. Dissertation, LMU München: Faculty of Medicine

Abstract

A serotonergic dysfunction was suggested to be involved into the biological susceptibility of suicidal behaviour. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, is a significant regulating factor in the serotonergic system. Recently the A-6526G, and G-5806T and A-779C polymorphisms of the TPH 1 gene were identified and suggested to be associated with suicidal behaviour, but study results are conflicting. We examined a possible association of the A-6526G, and G-5806T and A-779C polymorphisms with suicide attempts in a sample of 80 alcohol-dependent individuals with a history of at least one suicide attempt. This group was analysed in comparison with 241 alcohol-dependent subjects without such a history. No significant relationship between haplotype and genotype distribution and allele frequencies of these polymorphisms with suicide attempts were detected. Furthermore, no association with number of suicide attempts and TPH haplotypes were found. Our data do not support the hypothesis of A-6526G, G-5806T or A-779C polymorphisms to be associated with suicide attempts in alcohol-dependent individuals.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: Suicidal behaviour, alcohol-dependent individuals,polymorphisms,Tryptophan hydroxylase
• Subjects: 600 Technology, Medicine > 610 Medical sciences and medicine; 600 Technology, Medicine
• Faculties: Faculty of Medicine
• Language: German
• Date of oral examination: 7. March 2007
• 1. Referee: Soyka, Michael
• Signature of the printed copy: 0700/UMD 12014