Well, Harald (2005): Multi-Slice-Computertomographie an der distalen Radiusmetaphyse: Korrelation der kortikalen Knochenstruktur mit Geschlecht, Alter, osteoporotischem Status und mechanischer Kompetenz. Dissertation, LMU München: Faculty of Medicine |
Preview |
PDF
Well_Harald.pdf 749kB |
Abstract
We explore the relationship of region-specific densitometric and geometry-based (cortical) parameters at the distal radial metaphysis with gender, age, and osteoporotic status, using multislice computed tomography (CT). We specifically test the hypothesis that these parameters can improve the prediction of mechanical strength of the distal radius vs bone mass (bone mineral content [BMC]). The BMC was determined in 56 forearm specimens with peripheral dual-energy X-ray absorptiometry (DXA). Trabecular and cortical density and geometric properties of the metaphyseal cortex were determined using multislice CT and proprietary image analysis software. Specimens were tested to failure in a fall simulation, maintaining the integrity of the elbow joint and hand. Women displayed significantly lower failure strength (-34%), BMC (-35%), trabecular density (-26%), and cortical area (-12%) than men. The reduction of trabecular density with age and osteoporotic status was stronger than that of cortical density or thickness. DXA explained approx 50% (r2) of the variability in bone failure loads. This proportion was slightly increased (55%) when adding geometry-based parameters. The study suggests that high-resolution tomographic measurements with current clinical imaging methodology can marginally improve the prediction of mechanical failure strength. Further efforts are required to improve spatial resolution for determining metaphyseal cortical properties clinically.
Item Type: | Theses (Dissertation, LMU Munich) |
---|---|
Keywords: | multislice computed tomography (CT), dual-energy X-ray absorptiometry (DXA), fall simulation, loco-typico fracture |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | German |
Date of oral examination: | 14. July 2005 |
1. Referee: | Eckstein, Felix |
MD5 Checksum of the PDF-file: | 52f0aa1aeb950f8a3b3a003d7d71640d |
Signature of the printed copy: | 0700/UMD 11206 |
ID Code: | 3963 |
Deposited On: | 18. Aug 2005 |
Last Modified: | 24. Oct 2020 10:22 |