Vergleich von microRNA-Expressionsprofilen aus Blut- und Serumproben und dem arteriosklerotischen Risikoprofil bei Patienten mit arteriosklerotisch bedingten Erkrankungsbildern

Doege, Alexander (2026): Vergleich von microRNA-Expressionsprofilen aus Blut- und Serumproben und dem arteriosklerotischen Risikoprofil bei Patienten mit arteriosklerotisch bedingten Erkrankungsbildern. Dissertation, LMU München: Medizinische Fakultät

Abstract

Atherosclerosis is a multifactorial, systemic disease of the arterial system and a leading cause of cardiovascular diseases worldwide. It progresses silently over time, characterized by inflammation, narrowing of blood vessels, and weakening of the vessel walls, ultimately leading to various clinical conditions. Early detection is crucial for effective management. This study investigates the expression of microRNAs (miRNAs), non-coding RNA molecules that regulate gene expression and influence cellular processes, as potential biomarkers for atherosclerosis-related diseases. Serum samples from patients with abdominal aortic aneurysm, coronary artery disease, carotid stenosis, and peripheral arterial disease, alongside healthy controls, were analyzed. Twenty-seven miRNAs showed significant differential expression between patient and control groups, with specific miRNAs associated with particular diseases. Notably, some of these miRNAs have been previously linked to atherosclerosis, supporting their relevance. No correlation was found between miRNA expression and traditional risk factors. These findings suggest that disease-specific miRNA profiles could serve as novel biomarkers for early diagnosis and risk assessment, warranting further research into their biological roles and clinical applications.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: microRNA, Arteriosklerose, Biomarker
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Deutsch
• Datum der mündlichen Prüfung: 15. Januar 2026
• 1. Bericht­erstatter:in: Schelling, Gustav