Dasgupta, Bikram (2024): Specialized fibroblasts in wound healing. Dissertation, LMU München: Faculty of Medicine |
PDF
Dasgupta_Bikram.pdf 3MB |
Abstract
Connective tissue fibroblasts are the primary cell type influencing and choreographing wound healing outcomes. We have previously identified a diversity of fibroblast cell types, of which one such population termed EPFs (Engrailed-lineage positive fibroblasts) undergo collective cell migration towards the center of the wound to generate scars (Jiang et al., 2020). The EPF cell lineage inhabits all layers of skin connective tissue (papillary, reticular, hypodermal, fascia), highlighting the need for a deeper understanding of the anatomic origins and differentiation trajectories of this pro-scarring fibroblast subset during wound healing stages. In this study, we aimed to investigate the mechanisms underlying skin tissue healing by examining the coordination of swelling, contraction, and scar formation. We focused on a specific group of fibroblast progenitor cells that express CD201 exclusively in fascia, which is the innermost layer of connective tissue in the skin.
Item Type: | Theses (Dissertation, LMU Munich) |
---|---|
Keywords: | Skin wound healing, Fibroblasts, CD201+ progenitor cells, Differentiation pathways, Retinoic acid, Hypoxia |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | English |
Date of oral examination: | 1. August 2024 |
1. Referee: | Behr, Jürgen |
MD5 Checksum of the PDF-file: | 7ff1fd4ca379d5353f5a172a1de6c5d7 |
Signature of the printed copy: | 0700/UMD 21932 |
ID Code: | 34040 |
Deposited On: | 16. Sep 2024 12:02 |
Last Modified: | 16. Sep 2024 12:02 |