Specialized fibroblasts in wound healing

Dasgupta, Bikram (2024): Specialized fibroblasts in wound healing. Dissertation, LMU München: Medizinische Fakultät

Abstract

Connective tissue fibroblasts are the primary cell type influencing and choreographing wound healing outcomes. We have previously identified a diversity of fibroblast cell types, of which one such population termed EPFs (Engrailed-lineage positive fibroblasts) undergo collective cell migration towards the center of the wound to generate scars (Jiang et al., 2020). The EPF cell lineage inhabits all layers of skin connective tissue (papillary, reticular, hypodermal, fascia), highlighting the need for a deeper understanding of the anatomic origins and differentiation trajectories of this pro-scarring fibroblast subset during wound healing stages. In this study, we aimed to investigate the mechanisms underlying skin tissue healing by examining the coordination of swelling, contraction, and scar formation. We focused on a specific group of fibroblast progenitor cells that express CD201 exclusively in fascia, which is the innermost layer of connective tissue in the skin.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Skin wound healing, Fibroblasts, CD201+ progenitor cells, Differentiation pathways, Retinoic acid, Hypoxia
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 1. August 2024
• 1. Bericht­erstatter:in: Behr, Jürgen