Blood coagulation factors as possible risk factors for cardiovascular diseases in a population-based cross-sectional study

Erhard, Anna (2024): Blood coagulation factors as possible risk factors for cardiovascular diseases in a population-based cross-sectional study. Dissertation, LMU München: Medizinische Fakultät

Abstract

Background and purpose: Even though many risk factors for cardiovascular diseases (CVD), especially for myocardial infarction (MI) and ischemic stroke (IS), are already well known and researched, there are still not enough representative population-based studies in the field of primary prevention, which investigated deep vein thrombosis (DVT) and pulmonary embolism (PE). Particularly, there is little research on blood coagulation factors and their impact as possible risk factors on venous thrombosis (VT) in the adult population. Methods: The prevalence of common risk factors of CVD were described in the population-based KORA-Fit study (n = 3,059). In a subsample (KORA-Fit (S4), n = 805) also the blood concentrations of hemostatic factors were determined and their association with the CVD risk was analyzed. For statistical analysis multivariable logistic regression models were used. Results: In KORA-Fit study overall 9.7% of the participants had been diagnosed with MI, IS or VT. 4.6% of all participants suffered from VT (3.7% men and 5.3% women). Participants with a VT diagnosis were older, had higher Body Mass Index, suffered from diabetes mellitus more often (14.5% versus 7.8% in participants without VT) and took more anticoagulants (17.9%) and other medication (30.7%). Regarding clinical laboratory parameters lower glomerular filtration rate, higher liver enzymes (GGT, AST, ALT) and higher levels of inflammatory markers (hsCRP) in participants with VT were observed. The regression analysis indicated, that higher levels of fibrinogen are associated with higher risk of VT and MI. Factor VIII showed positive correlation only to VT. Plasma protein C had, however, an inverse association with VT. There was no correlation between analyzed blood coagulation factors and the prevalence of ischemic stroke. Conclusions: In this population-based study a significant correlation between blood coagulation factors and cardiovascular diseases was observed. The evaluation of hemostatic factors in the adult population, such as fibrinogen, factor VIII, or protein C may help to develop the field of primary prevention of CVD and should be a subject of further research.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 1. Juli 2024
• 1. Bericht­erstatter:in: Linseisen, Jakob