Arshadipour, Ava (2024): Multimorbidity and mortality: evidence from epidemiological tudies in older adults. Dissertation, LMU München: Faculty of Medicine |
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Abstract
The coexistence of several chronic diseases is very common in older adults, making it crucial to understand multimorbidity (MM) patterns and associated mortality. We aimed to determine the prevalence of MM and common chronic disease combinations, as well as their impact on mortality in men and women aged 65 years and older using the population-based KORA-Age study, based in South of Germany. The chronic disease status of the participants was determined in 2008/9, and mortality status was followed up until 2016. MM was defined as having at least two chronic diseases. We used Cox proportional hazard models to calculate the hazard ratios (HRs) and the 95% confidence intervals (CIs) for associations between MM and all-cause mortality. During the study period 495 men (24.6%) and 368 women (17.4%) died. Although the MM prevalence was almost the same in men (57.7%) and women (60.0%), the overall effect of MM on mortality was higher in men (HR: 1.81, 95% CI: 1.47–2.24) than in women (HR: 1.28, 95% CI: 1.01–1.64; p-value for interaction <0.001). The type of disease included in the MM patterns had a significant impact on mortality risk. For example, when both heart disease and diabetes were included in the combinations of two and three diseases, the mortality risk was highest. The risk of premature death does not only depend on the number of diseases but also on the specific disease combinations. In this study, life expectancy depended strongly on a few diseases, such as diabetes, hypertension, and heart disease.
Item Type: | Theses (Dissertation, LMU Munich) |
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Keywords: | Multimorbidity, Mortality, chronic disease, older people, sex differences, hazard ratios |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | English |
Date of oral examination: | 26. March 2024 |
1. Referee: | Peters, Annette |
MD5 Checksum of the PDF-file: | cf61537ca154e9846dbf1810fb0ffe89 |
Signature of the printed copy: | 0700/UMD 21782 |
ID Code: | 33591 |
Deposited On: | 28. Jun 2024 07:57 |
Last Modified: | 28. Jun 2024 07:57 |