The molecular insights into the pathogenesis of myocarditis

Böhm, Felicitas (2024): The molecular insights into the pathogenesis of myocarditis. Dissertation, LMU München: Faculty of Medicine

Abstract

Myocarditis is an inflammatory disease which is often triggered by cardiotropic viruses. Whereas myocardial inflammation resolves spontaneously in the majority of patients, acute inflammation can progress to subacute and chronic inflammation finally resulting in cardiac remodeling and heart failure. In contrast to the adaptive immune system, the role of innate immunity remains have not been elucidated so far. In this project, the aim is to discover detailed pathomechanisms during cardiac inflammation and identify new targets to treat myocarditis. This work postulates that the MK-LRP1-NET axis as well as the IFN-I pathway play a crucial role during EAM. Thus, the IFN-I pathway may represent a novel therapeutic target for the treatment of cardiac inflammation.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: Myocarditis, innate immune system, IFN-I, Midkine, adaptive immune system
• Subjects: 600 Technology, Medicine; 600 Technology, Medicine > 610 Medical sciences and medicine
• Faculties: Faculty of Medicine
• Language: English
• Date of oral examination: 12. February 2024
• 1. Referee: Bartelt, Alexander
• Signature of the printed copy: 0700/UMD 21678