The molecular insights into the pathogenesis of myocarditis

Böhm, Felicitas (2024): The molecular insights into the pathogenesis of myocarditis. Dissertation, LMU München: Medizinische Fakultät

Abstract

Myocarditis is an inflammatory disease which is often triggered by cardiotropic viruses. Whereas myocardial inflammation resolves spontaneously in the majority of patients, acute inflammation can progress to subacute and chronic inflammation finally resulting in cardiac remodeling and heart failure. In contrast to the adaptive immune system, the role of innate immunity remains have not been elucidated so far. In this project, the aim is to discover detailed pathomechanisms during cardiac inflammation and identify new targets to treat myocarditis. This work postulates that the MK-LRP1-NET axis as well as the IFN-I pathway play a crucial role during EAM. Thus, the IFN-I pathway may represent a novel therapeutic target for the treatment of cardiac inflammation.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Myocarditis, innate immune system, IFN-I, Midkine, adaptive immune system
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 12. Februar 2024
• 1. Bericht­erstatter:in: Bartelt, Alexander