Influence of the autonomic nervous system on cardiac arrhythmogenesis

Schüttler, Dominik (2023): Influence of the autonomic nervous system on cardiac arrhythmogenesis = Einfluss des autonomen Nervensystems auf die kardiale Arrhythmogenese. Habilitationsschrift, LMU München: Medizinische Fakultät

Abstract

The autonomic nervous system (ANS) modulates our cardiorespiratory system providing physiological adaptation in times of rest, stress, or exercise. Imbalances in sympathetic and parasympathetic activities are tightly connected to the development of cardiovascular diseases. To non-invasively assess this fine-tuning between sympathetic and parasympathetic influences on cardiac function, various ECG-based biomarkers have been developed over the past decades. However, little is known how these ECG-based biomarkers behave under certain physiological and environmental changes. Thus, with these research projects we aimed at further investigating the influence of environmental, physiological, and pathological conditions on autonomic nervous function and the ECG-based biomarker PRD. Additionally, we intended to develop a porcine model of IHF with a proarrhythmic phenotype allowing to reliably investigate arrhythmia-related remodeling processes especially on autonomic level.

• Dokumententyp: Habilitationsschriften
• Keywords: autonomic function, arrhythmia, animal model, ECG, biomarker
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 2023