Oxidation of modified DNA nucleobases

Korotenko, Vasilii (2023): Oxidation of modified DNA nucleobases: computational study. Dissertation, LMU München: Fakultät für Chemie und Pharmazie

Abstract

In this work, the oxidizing properties of oxygen-centered radicals and the reducing properties of epigenetically modified DNA bases were studied. Special attention was paid to the equilibrium of the hydration reaction of 5-formylcytosine, because the corresponding hydrate product can be very easily oxidized. All this together allowed us to propose and thermodynamically evaluate the mechanism of the 1,5-Dimethylcytosine autoxidation reaction.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: epigenetics, nucleobases, radicals, computational chemistry, DFT
• Themengebiete: 500 Naturwissenschaften und Mathematik ; 500 Naturwissenschaften und Mathematik > 540 Chemie
• Fakultäten: Fakultät für Chemie und Pharmazie
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 3. März 2023
• 1. Bericht­erstatter:in: Zipse, Hendrik