| Korotenko, Vasilii (2023): Oxidation of modified DNA nucleobases: computational study. Dissertation, LMU München: Faculty of Chemistry and Pharmacy |
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Korotenko_Vasilii.pdf 17MB |
DOI: 10.5282/edoc.32298
Abstract
In this work, the oxidizing properties of oxygen-centered radicals and the reducing properties of epigenetically modified DNA bases were studied. Special attention was paid to the equilibrium of the hydration reaction of 5-formylcytosine, because the corresponding hydrate product can be very easily oxidized. All this together allowed us to propose and thermodynamically evaluate the mechanism of the 1,5-Dimethylcytosine autoxidation reaction.
| Item Type: | Theses (Dissertation, LMU Munich) |
|---|---|
| Keywords: | epigenetics, nucleobases, radicals, computational chemistry, DFT |
| Subjects: | 500 Natural sciences and mathematics 500 Natural sciences and mathematics > 540 Chemistry and allied sciences |
| Faculties: | Faculty of Chemistry and Pharmacy |
| Language: | English |
| Date of oral examination: | 3. March 2023 |
| 1. Referee: | Zipse, Hendrik |
| MD5 Checksum of the PDF-file: | 17238073ca74cd439ddd98922e04af9a |
| Signature of the printed copy: | 0001/UMC 29955 |
| ID Code: | 32298 |
| Deposited On: | 25. Oct 2023 13:39 |
| Last Modified: | 25. Oct 2023 13:40 |
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