Kochsiek, Janna (2023): Wiederholte Schädelhirntraumata im American Football und ihre Auswirkungen auf die Mikrostruktur des Gehirns. Dissertation, LMU München: Faculty of Medicine |
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Abstract
Diese kumulative Dissertation basiert auf zwei Originalarbeiten, die beide im Sommer 2021 in wissenschaftlichen Fachzeitschriften veröffentlicht wurden (“ Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players” im Journal of Magnetic Resonance Imaging (Erstautorenschaft) und “Age at First Exposure to Tackle Football is Associated with Cortical Thickness in Former Professional American Football Players” im Journal Cerebral Cortex (Mitautorenschaft)). Beide Publikationen untersuchen die langfristigen Auswirkungen repetitiver, klinisch- und subklinisch verlaufender Kopferschütterungen (englisch: repetitive head impacts [RHI]) auf die Hirnstruktur anhand einer Kohorte ehemaliger American Football Spieler der National Football League (NFL). Die Daten entstammen der amerikanischen Studie „Diagnosing and Evaluating Traumatic Encephalopathy using Clinical Tests“ (DETECT). Grundlage der Bildgebung waren T1-gewichtete und diffusionsgewichtete Bilder der Magnetresonanztomographie (MRT). In Arbeit 1 werden die langfristigen Auswirkungen der Exposition gegenüber wiederholten Schädelhirntraumata auf die weiße Substanz - hier das Corpus Callosum (CC) - untersucht. Des Weiteren wird der Zusammenhang zwischen mikrostrukturellen Veränderungen des CC und dem im Blutplasma gemessenen Protein Tau untersucht. Arbeit 2 setzt das Alter der Probanden bei Aufnahme der Kontaktsportart (englisch: age at first exposure [AFE]) in Relation zur grauen Substanz anhand der kortikalen Dicke in verschiedenen Hirnarealen im höheren Lebensalter. Beide Publikationen explorieren zudem die Assoziation von Mikrostruktur und kognitiver Funktion.
Abstract
This cumulative dissertation is based on two original papers, both published in scientific journals in the summer of 2021 (" Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players" in the Journal of Magnetic Resonance Imaging (first authorship) and "Age at First Exposure to Tackle Football is Associated with Cortical Thickness in Former Professional American Football Players" in the Journal Cerebral Cortex (co-authorship)). Both publications examine the long-term effects of repetitive, clinical, and subclinical head impacts (RHI) on brain structure in a cohort of former American football players from the National Football League (NFL). The data originate from the american study "Diagnosing and Evaluating Traumatic Encephalopathy using Clinical Tests" (DETECT). Imaging was based on T1-weighted and diffusion-weighted images of magnetic resonance imaging (MRI). Paper 1 investigates the long-term effects of exposure to repetitive head impacts (RHI) on white matter - in this case, the corpus callosum (CC). Furthermore, the relationship between microstructural changes of the CC and the protein tau measured in blood plasma is investigated. Paper 2 relates the age at first exposure (AFE) of subjects to gray matter cortical thickness in different brain areas at advanced ages. Both publications also explore the association of microstructure and cognitive function.
Item Type: | Theses (Dissertation, LMU Munich) |
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Keywords: | Chronisch-traumatische Enzephalopathie, Schädel-Hirn-Traumata, MRT, Diffusions-Tensor-Bildgebung, American Football |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | German |
Date of oral examination: | 4. May 2023 |
1. Referee: | Koerte, Inga |
MD5 Checksum of the PDF-file: | 955c4aae3c3574610ca812a20c182cba |
Signature of the printed copy: | 0700/UMD 21240 |
ID Code: | 31901 |
Deposited On: | 31. Jul 2023 13:33 |
Last Modified: | 14. Aug 2023 12:30 |