Suraya, Anna (2021): Asbestos exposure in lung cancer: a hospital-based case control study in Indonesia. Dissertation, LMU München: Faculty of Medicine |
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Abstract
Indonesia has limited data on asbestos-related diseases despite abundant using. This study investigated the risk of occupational asbestos exposure for lung cancer development, utilizing a hospital-based case-control study. Subjects were patients who received a thoracic CT scan at Persahabatan Hospital, Jakarta. The cases had primary lung cancer confirmed by histology, the controls were negative for lung cancer. The cumulative occupational asbestos exposure was calculated by multiplying the exposure intensity by the years of exposure. The exposure intensity was obtained by adopting the weighted arithmetic mean value of asbestos exposure from a job-exposure matrix developed in Korea. The primary data analysis was based on logistic regression. The study included 696 subjects, with 336 cases and 360 controls. The chance of lung cancer for subjects exposed to asbestos was doubled (OR=2.04, 95% CI=1.21-3.42) compared with unexposed, and subjects with a cumulative asbestos exposure of 10 fiber-years or more even showed an OR of 3.08 (95% CI= 1.01-9.46). The OR of the combined effect between smoking and asbestos was 8.7 (95% CI=1.71-44.39); the interaction was consistent with an additive and multiplicative risk model. Asbestos exposure is associated with a higher chance of lung cancer. Improved policies are needed to protect the population from asbestos hazards.
Item Type: | Theses (Dissertation, LMU Munich) |
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Keywords: | lung cancer, asbestos, Indonesia |
Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine |
Faculties: | Faculty of Medicine |
Language: | English |
Date of oral examination: | 9. November 2021 |
1. Referee: | Nowak, Dennis |
MD5 Checksum of the PDF-file: | e6e88ef6b8ea372b3b3121382a9e54bb |
Signature of the printed copy: | 0700/UMD 20003 |
ID Code: | 28904 |
Deposited On: | 01. Dec 2021 10:03 |
Last Modified: | 01. Dec 2021 10:03 |