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Glykosylierungen des Thyroxin-bindenden Globulins
Glykosylierungen des Thyroxin-bindenden Globulins
Removal of N-glycosylation consensus sequences in hTBG-gene (SERPINA7-gene) results in no alteration in protein folding and binding of T4 . Destroying of all five N-glycosylation sites at once in the amino acid chain inhibits completely the export into the extracellular space but contrary any kind of glycosylation is actually basic and obviously needed for export from the cell. Non-glycosylated TBG is not exported into the medium.
TBG, Thyroxin, thyroxine, N-Glykosylierung, N-glycosylation, Proteinreifung, Proteinfaltung, protein folding, export of proteins
Wagner, Sandra
2020
German
Universitätsbibliothek der Ludwig-Maximilians-Universität München
Wagner, Sandra (2020): Glykosylierungen des Thyroxin-bindenden Globulins. Dissertation, LMU München: Faculty of Medicine
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Abstract

Removal of N-glycosylation consensus sequences in hTBG-gene (SERPINA7-gene) results in no alteration in protein folding and binding of T4 . Destroying of all five N-glycosylation sites at once in the amino acid chain inhibits completely the export into the extracellular space but contrary any kind of glycosylation is actually basic and obviously needed for export from the cell. Non-glycosylated TBG is not exported into the medium.