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Hager, Anastasia (2012): Studies towards total synthesis of polyketide natural products and alkaloids. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
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Abstract

Cascade reactions are powerful synthetic methods, which can be used to introduce several C-C bonds and chiral centers in only one step. This thesis deals with synthetic studies toward polyketide type I and type II natural products as well as alkaloids, which are based on cascade key steps. In the case of polyketide natural products A-74528 and divergolides C and D, synthetic key steps inspired by proposed biomimetic aldol and Michael cascade reactions were approached. The work towards stephadiamine, a norhasubanan alkaloid, was focused on the incorporation of homoconjugated addition/Mannich cascade reaction. In addition, a radical cyclization step, which is presumably incorporated in the biogenesis of ansalactam A, was investigated.