Hager, Anastasia (2012): Studies towards total synthesis of polyketide natural products and alkaloids. Dissertation, LMU München: Faculty of Chemistry and Pharmacy |
Preview |
PDF
Hager_Anastasia.pdf 21MB |
Abstract
Cascade reactions are powerful synthetic methods, which can be used to introduce several C-C bonds and chiral centers in only one step. This thesis deals with synthetic studies toward polyketide type I and type II natural products as well as alkaloids, which are based on cascade key steps. In the case of polyketide natural products A-74528 and divergolides C and D, synthetic key steps inspired by proposed biomimetic aldol and Michael cascade reactions were approached. The work towards stephadiamine, a norhasubanan alkaloid, was focused on the incorporation of homoconjugated addition/Mannich cascade reaction. In addition, a radical cyclization step, which is presumably incorporated in the biogenesis of ansalactam A, was investigated.
Item Type: | Theses (Dissertation, LMU Munich) |
---|---|
Keywords: | Polyketides, Cascade reactions, Alkaloids, Total synthesis |
Subjects: | 500 Natural sciences and mathematics 500 Natural sciences and mathematics > 540 Chemistry and allied sciences |
Faculties: | Faculty of Chemistry and Pharmacy |
Language: | English |
Date of oral examination: | 14. November 2012 |
1. Referee: | Trauner, Dirk |
MD5 Checksum of the PDF-file: | bb2e19847eb0de5032c8373df3e2f89d |
Signature of the printed copy: | 0001/UMC 20856 |
ID Code: | 15173 |
Deposited On: | 07. Jan 2013 12:47 |
Last Modified: | 24. Oct 2020 01:37 |