Untersuchungen zur entzündungshemmenden Wirkung von Cannabis sativa L.- Extrakten im Modell der Gewebekulturen

Nadig, Alexandra (2008): Untersuchungen zur entzündungshemmenden Wirkung von Cannabis sativa L.- Extrakten im Modell der Gewebekulturen. Dissertation, LMU München: Tierärztliche Fakultät

Abstract

In this study, which is a part of a project of the European Union, the anti-inflammatory effects of extracts of Cannabis sativa L. with a very low content of THC, were examined. Three varying extracts of cannabis were studied by the use of different cell models (microglia, chondrocytes, SK-N-H cells and monocytes) and their effects were analysed by enzymes immuno assay, enzyme linked immunosorbent assay and western blot. The proteins of interest were prostaglandin E2, cyclooxygenase- 2 and the cytokines interleukin-1β, interleukin-6 and tumornecrosisfactor-α. For the first time standardized plant extracts with very low THC content (below 0.3%) were tested on their anti-inflammatory effects.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Cannabis sativa L., PGE2, COX2, anti-inflammatory effect, Cannabinoids, Monocytes, Chondrocytes, Microglia, SK-Cells
• Themengebiete: 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie) ; 500 Naturwissenschaften und Mathematik
• Fakultäten: Tierärztliche Fakultät
• Sprache der Hochschulschrift: Deutsch
• Datum der mündlichen Prüfung: 18. Juli 2008
• 1. Bericht­erstatter:in: Schmahl, Wolfgang