Retrospektive Untersuchung der Erythrozyten-Glutathionperoxidase-Aktivitäten von Rinder-Patienten der Klinik für Wiederkäuer

Wittmeier, Doris (2008): Retrospektive Untersuchung der Erythrozyten-Glutathionperoxidase-Aktivitäten von Rinder-Patienten der Klinik für Wiederkäuer. Dissertation, LMU München: Tierärztliche Fakultät

Abstract

Retrospectively almost 14,000 erythrocytes glutathione peroxidase (eGSHPx) activities of cattle from the clinic for ruminants of the Ludwig Maximilian University of Munich were geographically mapped. The eGSHPx is the most important indirect marker for the selenium supply of mammals. There are significant eGSHPx activity differences between the singular years. This might be conditional upon the different weather and therefore different forage plant growth and inclusion of selenium into the plant tissues. Furthermore there are significant differences between the age-groups and sexes: the most considerable difference existed in the age-group of the heifers and young bulls (100 until 720 days). The female animals performed considerably worse than their male contemporaries. In contrast, dairy cows performed better than the adult bulls. The postcode eGSHPx medians were worked out from the farm eGSHPx medians. The map primarily contains the region of South Bavaria (administrative districts of Swabia, Upper Bavaria, and Lower Bavaria) in Germany. From the map it can be seen that the selenium supply in the Northern Pre-Alps (as far as Munich) is marginally adequate whereas the selenium supply in the Bavarian Tertiary Hill Country (to the north of Munich until the Danube River) is adequate. Only 0.59 % of the postcodes eGSHPx medians were deficient (< 60 U eGSHPx/g Hb), 1.53 % low-marginal (≤ 100 U eGSHPx/g Hb) and 2.59 % marginal (≤ 130 U eGSHPx/g Hb). There were no significant linear correlations between the eGSHPx activity and other laboratory parameters. Furthermore the findings of the clinical examination undertaken on admission of cattle with an eGSHPx activity under 200 U/g Hb from farms with a median above 200 U/g Hb were analysed retrospectively. Two age groups with several eGSHPx groups were constituted that were each composed half of selenium deficients and half of control animals: “Calves younger than 100 days“ (< 200 U/g Hb: n = 200; ≤ 130 U/g Hb: n = 334; ≤ 100 U/g Hb: n = 220; < 60 U/g Hb: n = 84) and “cattle 100 days and older“ (< 200 U/g Hb: n = 226; ≤ 130 U/g Hb: n = 110; ≤ 100 U/g Hb: n = 70). This procedure should guarantee that these animals did not have a primary or nutritive selenium deficiency (belief: whole live stock affected by selenium deficiency) but a secondary selenium deficiency conditional upon the pathology. Significant results arose in the group of the “calves younger than 100 days“ in the parameters “posture“ (p = 0.0137 and 0.0355), “nutritional condition“ (p = 0.0148), and “intestine/abomasum“ (p = 0.0327). Some significant results arose from the age group of “cattle 100 days and older”, namely of the parameters “runting” (p = 0.0036, 0.0358, and 0.0203), “infectious diseases” (malignant catarrhal fever, bovine virus diarrhoea/mucosal disease, listeriosis, and paratuberculosis) (p = 0.0043), and “viral diseases” (malignant catarrhal fever and bovine virus diarrhoea/mucosal disease) (p = 0.0378). This indicates that only severe and protracted diseases lead to secondary selenium deficiency whereas acute diseases can be rebelled by primarily selenium sufficient cattle without sinking into deficiency at once. The selenium deficient calves’ significantly worse “posture” is probably attributable to the general physical frailty due to selenium deficiency.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: cattle,glutathione peroxidase,selenium,selenium deficiency,bavaria
• Themengebiete: 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie) ; 500 Naturwissenschaften und Mathematik
• Fakultäten: Tierärztliche Fakultät
• Sprache der Hochschulschrift: Deutsch
• Datum der mündlichen Prüfung: 8. Februar 2008
• 1. Bericht­erstatter:in: Klee, Wolfgang