Scale-Up of Liposome Manufacturing

Wiggenhorn, Michael (2007): Scale-Up of Liposome Manufacturing: Combining High Pressure Liposome Extrusion with Drying Technologies. Dissertation, LMU München: Faculty of Chemistry and Pharmacy

Abstract

The study provides a comprehensive overview on different stabilization techniques for liposomal formulations. The selection of the appropriate technology for a particular formulation can thereby be based on several considerations. If free flowable particulate bulk material is desired the spraying-technologies are preferred over lyophilization. Another advantage of spraying-based technologies is the possibility to combine the liposome formation step and the drying step within the same process. It is a prerequisite for the selection of the stabilization technique that the integrity of the liposomes is preserved with the incorporated drug after the process. Spray-drying is related to a thermal stress for the formulation but only for a short time. For heat labile drugs processes with low process temperatures, e.g. freeze-drying, spray freeze-drying, inert-spray drying or supercritical drying are most adequate. However, for technologies with a freezing step a sufficient stabilization against freezing induced stress e.g. by the selection of appropriate cryoprotectors is needed.

• Item Type: Theses (Dissertation, LMU Munich)
• Subjects: 500 Natural sciences and mathematics > 540 Chemistry and allied sciences; 500 Natural sciences and mathematics
• Faculties: Faculty of Chemistry and Pharmacy
• Language: English
• Date of oral examination: 30. July 2007
• 1. Referee: Winter, Gerhard
• Signature of the printed copy: 0001/UMC 16909