Effects of a carbohydrate restricted diet on the metabolic state and progressive pancreatic beta-cell loss in transgenic mice expressing a dominant negative GIP receptor

Höfer, Martina (2007): Effects of a carbohydrate restricted diet on the metabolic state and progressive pancreatic beta-cell loss in transgenic mice expressing a dominant negative GIP receptor. Dissertation, LMU München: Tierärztliche Fakultät

Abstract

Aim of this study was to investigate the effects of a carbohydrate restricted diet on the metabolic state and the progressive loss of beta-cells in transgenic mice expressing a dominant negative GIP receptor. The expression pattern of the endogene and trasngenic GIP receptor, clinical parameters, and the number of beta-cells and islets were investigated among other things.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: GIP, diabetes, beta-cell number, islet number
• Themengebiete: 500 Naturwissenschaften und Mathematik ; 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie)
• Fakultäten: Tierärztliche Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 9. Februar 2007
• 1. Bericht­erstatter:in: Wanke, Rüdiger