| Zillies, Jan (2007): Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application. Dissertation, LMU München: Faculty of Chemistry and Pharmacy |
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Zillies_Jan.pdf 3MB |
DOI: 10.5282/edoc.6616
Abstract
The present work follows a course of analytical description, formulation development, and practical application of (NF-κB decoy oligonucleotide-loaded) gelatin nanoparticles. The introduction of asymmetrical flow field-flow fractionation (AF4) in the analysis of colloidal drug carrier systems was exemplarily described for gelatin nanoparticles (CHAPTER I), stable freeze-dried formulations of empty and oligonucleotide loaded gelatin nanoparticles were successfully developed (CHAPTER II), and gelatin nanoparticles were proven as effective tool for the targeted delivery of an NF-κB decoy oligonucleotide to Kupffer cells within a hepatic ischemia reperfusion rat model (CHAPTER III).
| Item Type: | Theses (Dissertation, LMU Munich) |
|---|---|
| Subjects: | 500 Natural sciences and mathematics > 540 Chemistry and allied sciences 500 Natural sciences and mathematics |
| Faculties: | Faculty of Chemistry and Pharmacy |
| Language: | English |
| Date of oral examination: | 2. February 2007 |
| 1. Referee: | Winter, Gerhard |
| MD5 Checksum of the PDF-file: | f608d5466d9b6ac269a7704cd960c6ac |
| Signature of the printed copy: | 0001/UMC 16060 |
| ID Code: | 6616 |
| Deposited On: | 26. Mar 2007 |
| Last Modified: | 24. Oct 2020 08:40 |
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