Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application

Zillies, Jan (2007): Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application. Dissertation, LMU München: Fakultät für Chemie und Pharmazie

Abstract

The present work follows a course of analytical description, formulation development, and practical application of (NF-κB decoy oligonucleotide-loaded) gelatin nanoparticles. The introduction of asymmetrical flow field-flow fractionation (AF4) in the analysis of colloidal drug carrier systems was exemplarily described for gelatin nanoparticles (CHAPTER I), stable freeze-dried formulations of empty and oligonucleotide loaded gelatin nanoparticles were successfully developed (CHAPTER II), and gelatin nanoparticles were proven as effective tool for the targeted delivery of an NF-κB decoy oligonucleotide to Kupffer cells within a hepatic ischemia reperfusion rat model (CHAPTER III).

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie ; 500 Naturwissenschaften und Mathematik
• Fakultäten: Fakultät für Chemie und Pharmazie
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 2. Februar 2007
• 1. Bericht­erstatter:in: Winter, Gerhard