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Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents
Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents
This work has been focused on the use of copper(I)-mediated anti-SN2’ allylic substitution reactions with non directing leaving groups. This proved to be a general and highly reliable method for the preparation of new chiral stereogenic centers in high enantioselectivity. Moreover a particular effort was made to apply this method to more complex systems, and compounds like alcohols, amines, alkenylsilanes or unsaturated nitriles could be successfully prepared in their enantiomerically enriched form.
allylic substitution, copper, zinc, quaternary center, asymmetric synthesis
Perrone, Sylvie
2006
English
Universitätsbibliothek der Ludwig-Maximilians-Universität München
Perrone, Sylvie (2006): Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents. Dissertation, LMU München: Faculty of Chemistry and Pharmacy
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Abstract

This work has been focused on the use of copper(I)-mediated anti-SN2’ allylic substitution reactions with non directing leaving groups. This proved to be a general and highly reliable method for the preparation of new chiral stereogenic centers in high enantioselectivity. Moreover a particular effort was made to apply this method to more complex systems, and compounds like alcohols, amines, alkenylsilanes or unsaturated nitriles could be successfully prepared in their enantiomerically enriched form.