Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents

Perrone, Sylvie (2006): Copper(I)-mediated anti-SN2’ Allylic Substitution Reactions with Diorganozinc Reagents. Dissertation, LMU München: Fakultät für Chemie und Pharmazie

Abstract

This work has been focused on the use of copper(I)-mediated anti-SN2’ allylic substitution reactions with non directing leaving groups. This proved to be a general and highly reliable method for the preparation of new chiral stereogenic centers in high enantioselectivity. Moreover a particular effort was made to apply this method to more complex systems, and compounds like alcohols, amines, alkenylsilanes or unsaturated nitriles could be successfully prepared in their enantiomerically enriched form.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: allylic substitution, copper, zinc, quaternary center, asymmetric synthesis
• Themengebiete: 500 Naturwissenschaften und Mathematik > 540 Chemie ; 500 Naturwissenschaften und Mathematik
• Fakultäten: Fakultät für Chemie und Pharmazie
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 11. Dezember 2006
• 1. Bericht­erstatter:in: Knochel, Paul