Analysis of the structure and function of dendrites and dendritic spines

Eberhardt, Florian (2023): Analysis of the structure and function of dendrites and dendritic spines. Dissertation, LMU München: Faculty of Biology

Abstract

A single pyramidal cell carries about 30,000 synapses, and almost all of them can be found on dendritic spines. Spines are, therefore, an integral part of neuronal architectures. They are also essential for the mammalian nervous system. Despite their importance in memory formation and the integration of synaptic input, many aspects of the function of dendritic spines remain under debate. Unfortunately, the small size of dendritic spines makes experimental investigation difficult, and a better understanding of their complex interactions with other parts of the nervous system requires the study of various aspects across different scales, including molecular organization, morphology, and the dendritic tree as a whole. Quantitative theoretical models are needed to reveal the function of dendritic spines. The objective of this thesis is to explore different aspects of the structure and function of dendritic spines and dendrites, and to develop simplified but accurate descriptions of these systems. By building on the relationships between these elements, this work aims to develop a solid theoretical framework to improve our understanding of dendritic spines' role in synaptic integration and plasticity.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: dendritic spines, dendrites, computational neuroscience, Poisson-Nernst-Planck equations, cable theory, actin cytoskeleton
• Subjects: 500 Natural sciences and mathematics; 500 Natural sciences and mathematics > 570 Life sciences
• Faculties: Faculty of Biology
• Language: English
• Date of oral examination: 26. October 2023
• 1. Referee: Herz, Andreas
• Signature of the printed copy: 0001/UMC 30152