Preclinical investigation of immunomodulatory thermosensitive liposomes

Heiß, Bettina Sonja (2023): Preclinical investigation of immunomodulatory thermosensitive liposomes. Dissertation, LMU München: Tierärztliche Fakultät

Abstract

Within this thesis, two relevant immunoadjuvants were encapsulated in DPPG2-TSL and the impact on pharmacokinetic, biodistribution and therapeutic efficacy evaluated in vivo, in comparison to un-encapsulated, free compound. For the first time, the STING agonist ADU-S100 (ADU) was loaded in DPPG2-TSL under two different osmotic conditions: hypo- and isosmotic and subsequently tested in vivo. In addition, the TLR 7/8 Agonist Resiquimod (R848) was formulated in DPPG2-TSL-R848 and subsequently tested in vivo. Overall, the encapsulation enhanced in vivo delivery of encapsulated compound and has shown great potential for future research.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Liposomes, Nanopartikel, Immunoncology, targeted delivery, preclinical
• Themengebiete: 500 Naturwissenschaften und Mathematik ; 500 Naturwissenschaften und Mathematik > 590 Tiere (Zoologie)
• Fakultäten: Tierärztliche Fakultät
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 22. Juli 2023
• 1. Bericht­erstatter:in: Hirschberger, Johannes