Expansion von T-Zellen seltener Spezifität mittels B-Zellen

Zentz, Caroline (2004): Expansion von T-Zellen seltener Spezifität mittels B-Zellen. Dissertation, LMU München: Faculty of Chemistry and Pharmacy

Abstract

I concentrated on the expansion of T cells specific against the oncogenic human papilloma virus 16 (HPV16), which are a very rare population in the blood of healthy donors as well as patients with HPV16-associated cancer. Instead of mature dendritic cells (DC) as antigen presenting cells, which are a potent but limitated system, I used activated B cells. I was able to expand cytotoxic active HPV-specific T cells to therapeutically relevant cell numbers. I analysed the T cell receptors of the E7-specific T cells well as their avidity to get a first idea of clonality and avidity of HPV-specific T cell pools.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: HPV, T cells, B cells, EBV, adoptive therapy, CD40L
• Subjects: 500 Natural sciences and mathematics; 500 Natural sciences and mathematics > 540 Chemistry and allied sciences
• Faculties: Faculty of Chemistry and Pharmacy
• Language: German
• Date of oral examination: 10. November 2004
• 1. Referee: Hammerschmidt, Wolfgang
• Signature of the printed copy: 0001/UMC 14122