Metalation and Halogen-Lithium exchange of sensitive substrates and mild ester homologation in continuous flow

Ganiek, Maximilian (2018): Metalation and Halogen-Lithium exchange of sensitive substrates and mild ester homologation in continuous flow. Dissertation, LMU München: Fakultät für Chemie und Pharmazie

Abstract

Microflow setups offer enhanced residence time control, mixing, and heat transfer compared to batch chemistry. These features make them ideal for reactions employing unstable, highly reactive reagents. This work focused on applying these features of continuous flow setups to metalation, halogen-metal exchange and enolate chemistry. Additionally, the synthesis and derivatization of a novel heterocyclic scaffold by batch methods was described.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: Metalorganic reagents, Organic synthesis, Continuous flow microreactors
• Themengebiete: 500 Naturwissenschaften und Mathematik ; 500 Naturwissenschaften und Mathematik > 540 Chemie
• Fakultäten: Fakultät für Chemie und Pharmazie
• Sprache der Hochschulschrift: Englisch
• Datum der mündlichen Prüfung: 18. Oktober 2018
• 1. Bericht­erstatter:in: Knochel, Paul