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Metalation and Halogen-Lithium exchange of sensitive substrates and mild ester homologation in continuous flow
Metalation and Halogen-Lithium exchange of sensitive substrates and mild ester homologation in continuous flow
Microflow setups offer enhanced residence time control, mixing, and heat transfer compared to batch chemistry. These features make them ideal for reactions employing unstable, highly reactive reagents. This work focused on applying these features of continuous flow setups to metalation, halogen-metal exchange and enolate chemistry. Additionally, the synthesis and derivatization of a novel heterocyclic scaffold by batch methods was described.
Metalorganic reagents, Organic synthesis, Continuous flow microreactors
Ganiek, Maximilian
2018
English
Universitätsbibliothek der Ludwig-Maximilians-Universität München
Ganiek, Maximilian (2018): Metalation and Halogen-Lithium exchange of sensitive substrates and mild ester homologation in continuous flow. Dissertation, LMU München: Faculty of Chemistry and Pharmacy
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Abstract

Microflow setups offer enhanced residence time control, mixing, and heat transfer compared to batch chemistry. These features make them ideal for reactions employing unstable, highly reactive reagents. This work focused on applying these features of continuous flow setups to metalation, halogen-metal exchange and enolate chemistry. Additionally, the synthesis and derivatization of a novel heterocyclic scaffold by batch methods was described.