Über den Einfluss von mehrfach ungesättigten Fettsäuren auf kutane Mastzellen und eosinophile Granulozyten bei Hunden mit atopischer Dermatitis

Denk, Daniela (2009): Über den Einfluss von mehrfach ungesättigten Fettsäuren auf kutane Mastzellen und eosinophile Granulozyten bei Hunden mit atopischer Dermatitis. Dissertation, LMU München: Faculty of Veterinary Medicine

Abstract

The aim of this double-blinded, randomised and placebo-controlled study was to assess the potential influence of polyunsaturated fatty acids on the inflammatory infiltrate in the skin of twenty-eight mixed breed dogs diagnosed with atopic dermatitis. The animals ranged from 1 to 10 years of age. They were assigned to one of three groups and supplemented for ten weeks with flax seed oil, a commercial fatty acid product or a placebo. Skin punch biopsy specimens from the lateral thorax were taken prior to and at the end of the trial. Clinical signs as well as pruritus intensity were evaluated by owner pruritus scores and clinician lesion scores. The number of mast cells and eosinophils per mm2 within the epidermis and dermis were quantified before and after supplementation by utilisation of Image Analysis Software. There was no significant difference between cell counts before and after the study nor when comparing groups amongst themselves. However, a positive correlation between cell counts and the pruritus intensity as well as cell counts and clinical signs was observed.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: Atopic dermatitis, Dogs, Eosinophils, Histopathology, Mast cells, Morphometric analysis, Polyunsaturated fatty acids (PUFA), Skin
• Subjects: 500 Natural sciences and mathematics; 500 Natural sciences and mathematics > 590 Zoological sciences
• Faculties: Faculty of Veterinary Medicine
• Language: German
• Date of oral examination: 6. February 2009
• 1. Referee: Hermanns, Walter
• Signature of the printed copy: 0001/UMC 17998