| Simonis, Christopher (2009): Molekulare Klonierung, stabile Transfektion und funktionelle Expression der murinen Chemokinrezeptoren Ccr2 und Ccr5. Dissertation, LMU München: Faculty of Medicine |
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PDF
Simonis_Christopher.pdf 2334Kb |
Abstract
The two chemokine receptors CCR2 and CCR5 play important roles in the recruitment and activation of monocytes/macrophages and T-lymphocytes at sites of infection and inflammation. To further examine their function, I cloned the two murine chemokine receptors Ccr2 and Ccr5 from genomic mouse DNA by a PCR-based cloning strategy and functionally expressed them in stably transfected CHO-cells. These cells were used to generate the first monoclonal antibodies against Ccr2 and Ccr5.
| Item Type: | Thesis (Dissertation, LMU Munich) | |
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| Subjects: | 600 Technology, Medicine 600 Technology, Medicine > 610 Medical sciences and medicine | |
| Faculties: | Faculty of Medicine | |
| Language: | German | |
| Date Accepted: | 26. March 2009 | |
| 1. Referee: | Schlöndorff, Detlef | |
| Persistent Identifier (URN): | urn:nbn:de:bvb:19-99950 | |
| MD5 Checksum of the PDF-file: | 0db21ab744b08fd4b38f7a93054ed439 | |
| Signature of the printed copy: | 0700/UMD 13232 | |
| ID Code: | 9995 | |
| Deposited On: | 19. May 2009 08:35 | (UTC) |
| Last Modified: | 16. Oct 2012 08:27 | (UTC) |
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