Einflussfaktoren auf Transplantatüberleben und Transplantatfunktion nach Nierenlebendspende in Abhängigkeit der Sequenz Lebendspende-Kadaverspende versus Kadaverspende-Lebendspende

Baldauf, Benito-Jonas (2013): Einflussfaktoren auf Transplantatüberleben und Transplantatfunktion nach Nierenlebendspende in Abhängigkeit der Sequenz Lebendspende-Kadaverspende versus Kadaverspende-Lebendspende. Dissertation, LMU München: Medizinische Fakultät

Abstract

Since allograft survival is limited after living-related kidney transplantation (LRKT), the necessity of re-transplantation following LRKT increases. Information using living-related- versus deceased donor allografts is sparse. The outcome after kidney re-transplantation in respect to second graft origin was investigated. Primary LR- (pLR, n=239), second LR- (sLR, n=26) or deceased donor following LR transplantations (sDD, n=11) were compared. Analyses included patient and graft survival, frequency of rejections, re-surgery, immunological risk and graft function. Acute rejections, HLA-mismatch and delayed graft function (DGF) and re-surgery influenced survival. Graft survival following re-transplantation of living-related and deceased donor grafts is not necessarily reduced compared to pLRKT. Differences in factors, impacting graft and patient survival, in particular defining immunological risk, were balanced in comparisons between the groups.

• Dokumententyp: Dissertationen (Dissertation, LMU München)
• Keywords: living related kidney transplant, secondary living related, primary living related, secondary deceased donor allograft, function, HLA, mismatch, transplantation
• Themengebiete: 600 Technik, Medizin, angewandte Wissenschaften ; 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit
• Fakultäten: Medizinische Fakultät
• Sprache der Hochschulschrift: Deutsch
• Datum der mündlichen Prüfung: 18. April 2013
• 1. Bericht­erstatter:in: Rentsch, Markus