Synaptic physiology of urocortin 3, an ancient pleiotropic neuropeptide

Pagella, Sara (2023): Synaptic physiology of urocortin 3, an ancient pleiotropic neuropeptide. Dissertation, LMU München: Graduate School of Systemic Neurosciences (GSN)

Abstract

Neuropeptides are relatively less known compared to classic neurotransmitters. However, they are frequently found in the brain of mammals. In particular, the neuropeptide Urocortin 3, an evolutionarily conserved neuropeptide that developed before the establishment of the hypothalamic pituitary adrenal stress axis, has a widespread expression in many organs and cell types in mice. In this work, we investigated the location and functional significance of the presence of Urocortin 3 in the auditory brainstem of laboratory mice and we described in detail, through thorough electrophysiological examinations both in vitro and in vivo, its role at a giant central nervous system synapse, the calyx of Held.

• Item Type: Theses (Dissertation, LMU Munich)
• Keywords: Neuropeptides, Synapses, Electrophysiology, Patch Clamp, Mouse Anatomy, Stress, Auditory System
• Subjects: 500 Natural sciences and mathematics; 500 Natural sciences and mathematics > 570 Life sciences
• Faculties: Graduate School of Systemic Neurosciences (GSN)
• Language: English
• Date of oral examination: 26. May 2023
• 1. Referee: Kopp-Scheinpflug, Conny
• Signature of the printed copy: 0001/UMC 32004