| Heiß, Bettina Sonja (2023): Preclinical investigation of immunomodulatory thermosensitive liposomes. Dissertation, LMU München: Faculty of Veterinary Medicine |
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Heiss_Bettina_Sonja.pdf 7MB |
DOI: 10.5282/edoc.32438
Abstract
Within this thesis, two relevant immunoadjuvants were encapsulated in DPPG2-TSL and the impact on pharmacokinetic, biodistribution and therapeutic efficacy evaluated in vivo, in comparison to un-encapsulated, free compound. For the first time, the STING agonist ADU-S100 (ADU) was loaded in DPPG2-TSL under two different osmotic conditions: hypo- and isosmotic and subsequently tested in vivo. In addition, the TLR 7/8 Agonist Resiquimod (R848) was formulated in DPPG2-TSL-R848 and subsequently tested in vivo. Overall, the encapsulation enhanced in vivo delivery of encapsulated compound and has shown great potential for future research.
| Item Type: | Theses (Dissertation, LMU Munich) |
|---|---|
| Keywords: | Liposomes, Nanopartikel, Immunoncology, targeted delivery, preclinical |
| Subjects: | 500 Natural sciences and mathematics 500 Natural sciences and mathematics > 590 Zoological sciences |
| Faculties: | Faculty of Veterinary Medicine |
| Language: | English |
| Date of oral examination: | 22. July 2023 |
| 1. Referee: | Hirschberger, Johannes |
| MD5 Checksum of the PDF-file: | bc8d03435753059bf8ee6dc6aa9e5eb2 |
| Signature of the printed copy: | 0001/UMC 31279 |
| ID Code: | 32438 |
| Deposited On: | 25. Jun 2025 14:00 |
| Last Modified: | 25. Jun 2025 14:01 |
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