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Dieckmann, Stephan (2008): Zum Osteosarkom: Eine vergleichende Literaturstudie. Dissertation, LMU München: Faculty of Veterinary Medicine
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Abstract

Osteosarcoma – a retrospective study In dogs osteosarcoma is rare, but it is the most common primary bone tumor diagnosed in dogs. Most osteosarcomas occur in large and older dogs. Most frequent location site of osteosarcoma in dog is the forderlimb. Diagnosis depends on histological evaluation, but in radiological examinations the typical signs are very characteristic. Dogs with osteosarcoma have an poor prognosis. In more than 90% of cases micrometastases have been developed at time of clinical presentation. Beeing treated or being not treated most of the dogs die on the effects of metastatic disease. Studies of the last years showed that the usage of different surgical and medical treatment options results in an improvement of quality of life and survival. The treatment options are both definitive and palliative. Chosing an definitive task for treatment of osteosarcoma the surgical treatment of the affected site by amputation or limb-sparing is the basic option. It must be combined with adjuvant treatment. The usage of cisplatin and/ -or doxorubicin results in an significant improvement of survival. With the usage of neoadjuvant treatment the tumor process can be minimized on a stage that improves surgical treatment and after operation the control of process, by downstaging. Is no chance for surgical treatment, palliative treatment options must be considered to provide pain control and an acceptable quality of life. In this case radiotherapy is an successful option.