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Nadig, Alexandra (2008): Untersuchungen zur entzündungshemmenden Wirkung von Cannabis sativa L.- Extrakten im Modell der Gewebekulturen. Dissertation, LMU München: Faculty of Veterinary Medicine
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Abstract

In this study, which is a part of a project of the European Union, the anti-inflammatory effects of extracts of Cannabis sativa L. with a very low content of THC, were examined. Three varying extracts of cannabis were studied by the use of different cell models (microglia, chondrocytes, SK-N-H cells and monocytes) and their effects were analysed by enzymes immuno assay, enzyme linked immunosorbent assay and western blot. The proteins of interest were prostaglandin E2, cyclooxygenase- 2 and the cytokines interleukin-1β, interleukin-6 and tumornecrosisfactor-α. For the first time standardized plant extracts with very low THC content (below 0.3%) were tested on their anti-inflammatory effects.