| Zillies, Jan (2007): Gelatin Nanoparticles for Targeted Oligonucleotide Delivery to Kupffer Cells - Analytics, Formulation Development, Practical Application. Dissertation, LMU München: Faculty of Chemistry and Pharmacy |
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PDF
Zillies_Jan.pdf 3871Kb |
Abstract
The present work follows a course of analytical description, formulation development, and practical application of (NF-κB decoy oligonucleotide-loaded) gelatin nanoparticles. The introduction of asymmetrical flow field-flow fractionation (AF4) in the analysis of colloidal drug carrier systems was exemplarily described for gelatin nanoparticles (CHAPTER I), stable freeze-dried formulations of empty and oligonucleotide loaded gelatin nanoparticles were successfully developed (CHAPTER II), and gelatin nanoparticles were proven as effective tool for the targeted delivery of an NF-κB decoy oligonucleotide to Kupffer cells within a hepatic ischemia reperfusion rat model (CHAPTER III).
| Item Type: | Thesis (Dissertation, LMU Munich) | |
|---|---|---|
| Subjects: | 600 Natural sciences and mathematics > 540 Chemistry and allied sciences 600 Natural sciences and mathematics | |
| Faculties: | Faculty of Chemistry and Pharmacy | |
| Language: | English | |
| Date Accepted: | 2. February 2007 | |
| 1. Referee: | Winter, Gerhard | |
| Persistent Identifier (URN): | urn:nbn:de:bvb:19-66165 | |
| MD5 Checksum of the PDF-file: | f608d5466d9b6ac269a7704cd960c6ac | |
| Signature of the printed copy: | 0001/UMC 16060 | |
| ID Code: | 6616 | |
| Deposited On: | 26. Mar 2007 | (UTC) |
| Last Modified: | 16. Oct 2012 08:05 | (UTC) |
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