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Frommeyer, Ute (2006): Studien zur Physiologie und Pathologie der Hämostase bei Schmuckschildkröten und grünen Leguanen. Dissertation, LMU München: Faculty of Veterinary Medicine
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Abstract

Plasmatic clotting times and number of thrombocytes were established in clinically healthy slider turtles and green iguanas as well as in animals with clinically conspicious symptoms. The used commercial reagents for prothrombin time, activated partial thromboplastin time and thrombin time proved reliable for the analysis of reptilian blood. The steel ball coagulo-meter as well as the coagulometer according to Schnitger and Gross can be used for meassuring. Altogether 239 blood samples of clinically healthy slider turtles were analysed and evaluated for genus, species, gender, age and season. Furthermore 67 clinically incon-spicuous green iguanas were available for the coagulation analysis. For the evaluation of the results the influence of age and gender were taken into consideration. For slider turtles as well as for green iguanas reference values for the three clotting parameters could be established because of the relatively close correspondence of the values determined twice in each sample and in repetition. In order to receive correct results it is of great importance to intermeadiatly analyse citrate plasma samples. Reference factors for the number of thrombocytes of green iguanas and slider turtles, which were manually counted, could also be defined. Apart from the coagulation diagnostics the examination of clinical blood chemistry and haematological blood parameters in animals with pathological changes gave important clues for the aetiology of hemostatic disorders, which were proved by the histological results of dissected patients. Serious hepatic dysfunctions mostly lead to a reduced synthesis of coagu-lation factors and therefore to coagulopathies. It is important to take into consideration that clinically evident symptoms do not always have to be connected with prolonged plasmatic clotting times. Hypovitaminosis k, disseminated intravascular coagulation, thrombocytopenia and vasopathies can also cause bleeding disorders. The results of the verification of the success of therapy of green iguanas, which were clinical-ly as well as laboratory diagnostically conspicous, coincide with the empirical experiences and show, that Phytomenadion for treatment of hypovitaminosis k is also suitable in reptile medicine. The control of the clotting time after application of Konakion ® (orally or intra-muscular) in slider turtles with increased parameters, which in most cases could be attributed to a reduced liver function, showed, that Phytomenadion has an at least temporary positive impact on the regeneration of the liver and in many cases lead to an improvement of values. In comparison to untreated animals the effect was especially apparent in the activated partial thromboplastin time.