| Stubenbord, Julia Petra (2006): Synergistische therapeutische Wirkung durch Inhibition der Phosphodiesterase VI und des Interleukin-1β converting Enzyms im murinen Kolitismodell. Dissertation, LMU München: Faculty of Veterinary Medicine |
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Stubenbord_Julia.pdf 4Mb |
Abstract
Abstract This study examined new strategies for pharmacological treatment in a mouse model of chronic inflammatory bowel disease. As clinical parameters we determined the lethality and clinical score which consisted of weight loss, presence or absence of diarrhea and blood in the faeces. Further, pathoanatomical and histological data were examined. To determine the effect of pharmacological treatment on the level of cytokines, the respective concentrations were measured in the colon. The aim of this study was to determine the effect of the ICE-inhibitor Pralnacasan and the PDE-4-inhibitor Rolipram on reducing colitis. We also assessed whether a combination of both drugs might have a synergistic effect. The results showed a clear therapeutic effect of Pralnacasan, whereas Rolipram was neither effective in the clinical outcome nor in changing cytokine levels. In contrast the combination of both drugs showed a synergistic effect which prevented both occurrence of colitis in clinical measurements and increase of cytokine levels. In summary, this study provides the first evidence that a combination of two drugs which act on different pathways provide a strong synergistic effect which can completely prevent the occurrence of colitis in a mouse model
| Item Type: | Thesis (Dissertation, LMU Munich) | |
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| Keywords: | mouse model, chronic inflammatory bowel disease,cytokines, ICE-inhibitor,PDE-4-inhibitor | |
| Subjects: | 600 Natural sciences and mathematics > 590 Zoological sciences 600 Natural sciences and mathematics | |
| Faculties: | Faculty of Veterinary Medicine | |
| Language: | German | |
| Date Accepted: | 28. July 2006 | |
| 1. Referee: | Ammer, Hermann | |
| Persistent Identifier (URN): | urn:nbn:de:bvb:19-59746 | |
| MD5 Checksum of the PDF-file: | 9c04f6c02b81368b8ebbfc35e8f926f5 | |
| Signature of the printed copy: | 0001/UMC 15844 | |
| ID Code: | 5974 | |
| Deposited On: | 13. Dec 2006 | (UTC) |
| Last Modified: | 16. Oct 2012 08:01 | (UTC) |