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Zentz, Caroline (2004): Expansion von T-Zellen seltener Spezifität mittels B-Zellen. Dissertation, LMU München: Faculty of Chemistry and Pharmacy
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Abstract

I concentrated on the expansion of T cells specific against the oncogenic human papilloma virus 16 (HPV16), which are a very rare population in the blood of healthy donors as well as patients with HPV16-associated cancer. Instead of mature dendritic cells (DC) as antigen presenting cells, which are a potent but limitated system, I used activated B cells. I was able to expand cytotoxic active HPV-specific T cells to therapeutically relevant cell numbers. I analysed the T cell receptors of the E7-specific T cells well as their avidity to get a first idea of clonality and avidity of HPV-specific T cell pools.